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Substitute plan pack · High school

🧬 Life Science: Biology

One printable 40-minute plan for each of the 18 lessons. A substitute can run any lesson with the lesson's 3D video and Movie. No account needed.

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How to use this pack
  1. Pick the lesson your class is on. Press Print this lesson (one page) or print the whole pack (one lesson per page).
  2. Leave the page with the lesson link. The substitute opens it on the board; no sign-in is needed.
  3. Questions and answers on each page come straight from the lesson. Answers are marked “for the teacher”.
  4. When printing, turn off “Headers and footers” in the print dialog for the cleanest page.

Lesson 1: Cells, organelles and homeostasis

Life Science: Biology · High schoolUnit 1: Cells and moleculesNYS standard: HS-LS1-1, HS-LS1-2, HS-LS1-3

Big idea: Cells work in systems to keep balance.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Your body stays at about 98.6°F whether it's hot or cold outside. That balance is homeostasis.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 3 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • This is an animal cell. Each organelle inside has a job, like workers in a city.
  • The nucleus keeps the DNA: the instructions for building the cell's proteins.
  • Mitochondria release energy from food and store it as ATP.
  • The cell membrane controls what enters and leaves the cell.
  • Plant cells add a stiff cell wall, chloroplasts for photosynthesis, and a big central vacuole.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Shivering when cold is an example of…

  • A. Negative feedback for homeostasis
  • B. Evolution

Answer (for the teacher): Negative feedback for homeostasis

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Organs working together form…

  • A. Organ systems
  • B. Cells

Answer (for the teacher): Organ systems

Leave on the board

  • Cells, organelles and homeostasis
  • Big idea: Cells work in systems to keep balance.
  • Memory trick: “Sense, signal, respond.”
  • Goal: 100%

Watch for this mistake

  • Thinking feedback always increases change.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 2: Body systems work together

Life Science: Biology · High schoolUnit 1: Cells and moleculesNYS standard: HS-LS1-2

Big idea: Body systems team up to keep you alive.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“When you sprint, your lungs, heart and muscles all speed up together.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 3 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Your body's organ systems each do a job: nervous, respiratory, circulatory, muscular and more.
  • When you sprint, your muscles need more oxygen, so your heart beats faster and you breathe faster.
  • The lungs take in oxygen, the heart pumps blood, and the blood carries oxygen to the muscles. Systems work as a team.
  • After a meal, blood sugar rises. The pancreas releases insulin, cells take in sugar, and the level comes back down.
  • When blood sugar drops, the pancreas releases glucagon, and the liver releases stored sugar.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

During exercise, heart rate rises mainly to…

  • A. Deliver more oxygen to muscles
  • B. Digest food faster

Answer (for the teacher): Deliver more oxygen to muscles

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

A model of body systems shows…

  • A. How the parts interact
  • B. Only one organ

Answer (for the teacher): How the parts interact

Leave on the board

  • Body systems work together
  • Big idea: Body systems team up to keep you alive.
  • Memory trick: “No system works alone.”
  • Goal: 100%

Watch for this mistake

  • Studying each organ as if it worked by itself.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 3: Biomolecules and enzymes

Life Science: Biology · High schoolUnit 1: Cells and moleculesNYS standard: HS-LS1-6

Big idea: Cells build big molecules from sugar's atoms.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Bread, butter, eggs and DNA are all built from carbon-based molecules.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 2 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Four kinds of big molecules build living things. Each is made from small building blocks.
  • Simple sugars like glucose link into long chains: starch and cellulose are carbohydrates.
  • Amino acids link into a chain, and the chain folds into a protein. The order decides the shape.
  • An enzyme is a protein that speeds up a reaction. The substrate fits its active site.
  • A molecule with the wrong shape does not fit, so this enzyme cannot act on it.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

An enzyme heated far above body temperature usually…

  • A. Changes shape and stops working
  • B. Works faster forever

Answer (for the teacher): Changes shape and stops working

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Enzymes ___ chemical reactions.

  • A. Speed up
  • B. Stop all

Answer (for the teacher): Speed up

Leave on the board

  • Biomolecules and enzymes
  • Big idea: Cells build big molecules from sugar's atoms.
  • Memory trick: “Shape = job.”
  • Goal: 100%

Watch for this mistake

  • Thinking enzymes get used up in each reaction.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 4: Photosynthesis and cellular respiration

Life Science: Biology · High schoolUnit 1: Cells and moleculesNYS standard: HS-LS1-5, HS-LS1-7

Big idea: Light → sugar → ATP.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Plants capture sunlight; every cell releases energy from sugar. They're opposite reactions.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 3 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Photosynthesis happens in chloroplasts: light energy, carbon dioxide and water make glucose and oxygen.
  • Cellular respiration happens in mitochondria: glucose and oxygen make carbon dioxide, water and ATP energy.
  • The products of photosynthesis are the reactants of respiration, and the other way around.
  • 6 CO2 plus 6 H2O makes C6H12O6 plus 6 O2. Count the atoms: 6 carbon, 12 hydrogen and 18 oxygen on each side.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Cellular respiration mainly happens in the…

  • A. Mitochondria
  • B. Chloroplast

Answer (for the teacher): Mitochondria

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Plants do…

  • A. Both
  • B. Only photosynthesis

Answer (for the teacher): Both

Leave on the board

  • Photosynthesis and cellular respiration
  • Big idea: Light → sugar → ATP.
  • Memory trick: “Plants make it; everyone burns it.”
  • Goal: 100%

Watch for this mistake

  • Thinking plants don't respire.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 5: Mitosis and cell differentiation

Life Science: Biology · High schoolUnit 1: Cells and moleculesNYS standard: HS-LS1-4

Big idea: Mitosis makes identical cells; differentiation gives them jobs.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“A scraped knee heals because skin cells divide to replace the lost ones.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 3 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Before dividing, the cell grows and copies all its DNA. This is interphase.
  • Prophase: the chromosomes coil up. Each one is now two identical sister chromatids.
  • Metaphase: spindle fibers line the chromosomes up in the middle.
  • Anaphase: the sister chromatids are pulled apart to opposite ends.
  • Telophase: two new nuclei form, and the cell pinches in two.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

A human skin cell with 46 chromosomes divides by mitosis. Chromosomes in each new cell?

Answer (for the teacher): 46

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Cells made by mitosis are…

  • A. Genetically identical
  • B. All different

Answer (for the teacher): Genetically identical

Leave on the board

  • Mitosis and cell differentiation
  • Big idea: Mitosis makes identical cells; differentiation gives them jobs.
  • Memory trick: “Mitosis copies; differentiation specializes.”
  • Goal: 100%

Watch for this mistake

  • Thinking different cell types have different DNA.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 6: Energy pyramids and carbon cycle

Life Science: Biology · High schoolUnit 2: EcosystemsNYS standard: HS-LS2-4, HS-LS2-5

Big idea: Energy drops; carbon cycles.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Only about 10% of energy passes up each level of a food chain.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 3 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • In a food web, arrows point from the food to the eater. They show which way energy flows.
  • An energy pyramid: producers at the bottom hold the most energy.
  • Only about 10 percent passes up to each next level. The rest is used for living or lost as heat.
  • Carbon cycles: plants take carbon dioxide from the air, animals eat plants, and respiration puts it back.
  • Burning fossil fuels releases carbon that was stored underground, adding carbon dioxide to the air.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Producers have 10,000 kcal. About how much reaches secondary consumers?

Answer (for the teacher): 100

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Decomposers return…

  • A. Nutrients
  • B. Sunlight

Answer (for the teacher): Nutrients

Leave on the board

  • Energy pyramids and carbon cycle
  • Big idea: Energy drops; carbon cycles.
  • Memory trick: “Ten percent climbs.”
  • Goal: 100%

Watch for this mistake

  • Thinking energy is recycled like matter.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 7: Populations and carrying capacity

Life Science: Biology · High schoolUnit 2: EcosystemsNYS standard: HS-LS2-1, HS-LS2-2

Big idea: Limited resources cap population growth.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Deer on Long Island with few predators can multiply until food runs short.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 2 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • With unlimited food, space and no predators, a population grows faster and faster: a J-shaped curve.
  • Real resources are limited, so growth slows and levels off: an S-shaped curve.
  • Limiting factors like food, water, space, predators and disease set the carrying capacity.
  • If resources increase, the carrying capacity goes up.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

A population of 100 doubles every year for 3 years. Size after 3 years?

Answer (for the teacher): 800

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Biodiversity is often measured by…

  • A. The number and variety of species
  • B. The number of rocks

Answer (for the teacher): The number and variety of species

Leave on the board

  • Populations and carrying capacity
  • Big idea: Limited resources cap population growth.
  • Memory trick: “J grows wild; S hits the ceiling.”
  • Goal: 100%

Watch for this mistake

  • Thinking populations can grow forever.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 8: Aerobic and anaerobic processes

Life Science: Biology · High schoolUnit 2: EcosystemsNYS standard: HS-LS2-3

Big idea: With oxygen, cells get far more energy.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Bread rises because yeast makes CO₂ without using oxygen.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 2 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Cellular respiration with oxygen happens in the mitochondria.
  • Aerobic respiration gives about 30 or more ATP per glucose. Without oxygen, cells get only 2.
  • Without enough oxygen, muscle cells ferment glucose into lactic acid. Yeast make ethanol and carbon dioxide.
  • Real life: the carbon dioxide from yeast makes bread dough rise.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Yeast making bread rise without oxygen is…

  • A. Anaerobic respiration (fermentation)
  • B. Photosynthesis

Answer (for the teacher): Anaerobic respiration (fermentation)

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Both aerobic and anaerobic processes…

  • A. Release energy from food
  • B. Make sunlight

Answer (for the teacher): Release energy from food

Leave on the board

  • Aerobic and anaerobic processes
  • Big idea: With oxygen, cells get far more energy.
  • Memory trick: “Air = more ATP.”
  • Goal: 100%

Watch for this mistake

  • Thinking anaerobic means no energy at all.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 9: Ecosystem stability and change

Life Science: Biology · High schoolUnit 2: EcosystemsNYS standard: HS-LS2-6

Big idea: Ecosystems recover from small changes; big ones reshape them.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Years after a forest fire, grasses, then shrubs, then trees return.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 2 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Primary succession starts on bare rock: lichens, then grasses, then shrubs, then a forest.
  • After a fire, soil is left, so plants come back much faster. That is secondary succession.
  • A stable ecosystem bounces back from small changes.
  • A big change, like a flood or a new invasive species, can reshape the whole ecosystem.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Plants regrowing in a burned field where soil remains is…

  • A. Secondary succession
  • B. Primary succession

Answer (for the teacher): Secondary succession

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Primary succession starts with…

  • A. No soil
  • B. Rich soil

Answer (for the teacher): No soil

Leave on the board

  • Ecosystem stability and change
  • Big idea: Ecosystems recover from small changes; big ones reshape them.
  • Memory trick: “No soil = primary.”
  • Goal: 100%

Watch for this mistake

  • Thinking a stable ecosystem never changes.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 10: Group behavior and survival

Life Science: Biology · High schoolUnit 2: EcosystemsNYS standard: HS-LS2-8

Big idea: Group behavior can raise survival and reproduction.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Fish swim in schools and wolves hunt in packs. Groups can help them survive.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • A fish swimming alone is an easy target for a predator.
  • In a school, many fish move together. The predator has trouble picking one out.
  • In a bigger group, each one's chance of being the one caught is smaller: safety in numbers.
  • Group behavior also helps hunters: a wolf pack can catch prey too big for one wolf.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Why do many fish swim in schools?

  • A. It is harder for a predator to catch one
  • B. Fish get lonely

Answer (for the teacher): It is harder for a predator to catch one

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

A claim about group behavior needs…

  • A. Evidence
  • B. Only opinion

Answer (for the teacher): Evidence

Leave on the board

  • Group behavior and survival
  • Big idea: Group behavior can raise survival and reproduction.
  • Memory trick: “Together = safer.”
  • Goal: 100%

Watch for this mistake

  • Thinking groups have no costs, like sharing food.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 11: Human impact and biodiversity

Life Science: Biology · High schoolUnit 2: EcosystemsNYS standard: HS-LS2-7, HS-LS4-6

Big idea: Diversity makes ecosystems resilient.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Invasive species, habitat loss and climate change reduce biodiversity. Solutions can help.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 2 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • A field with only one species: when a disease hits, the whole field dies.
  • A field with many species: the disease kills one kind, and the rest survive.
  • HIPPO names five threats to biodiversity: habitat loss, invasive species, pollution, population growth and overharvesting.
  • Losing species makes an ecosystem less able to recover from big changes.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Zebra mussels in the Great Lakes are…

  • A. Invasive species
  • B. Native producers

Answer (for the teacher): Invasive species

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Monocultures are…

  • A. Less resilient
  • B. More diverse

Answer (for the teacher): Less resilient

Leave on the board

  • Human impact and biodiversity
  • Big idea: Diversity makes ecosystems resilient.
  • Memory trick: “Many species, strong system.”
  • Goal: 100%

Watch for this mistake

  • Thinking one species doesn't matter.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 12: DNA to protein

Life Science: Biology · High schoolUnit 3: HeredityNYS standard: HS-LS1-1, HS-LS3-1

Big idea: DNA → RNA → protein.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“DNA is a recipe book; proteins are the dishes.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 3 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • The big idea: DNA to RNA to protein.
  • DNA is a double helix, a twisted ladder.
  • The rungs are base pairs: A pairs with T, and C pairs with G.
  • To use a gene, the cell unzips the DNA at that gene.
  • Transcription: RNA copies the gene. In RNA, U takes the place of T.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

DNA strand ATCG pairs with…

  • A. TAGC
  • B. ATCG

Answer (for the teacher): TAGC

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Mutations are…

  • A. Changes in DNA
  • B. Always harmful

Answer (for the teacher): Changes in DNA

Leave on the board

  • DNA to protein
  • Big idea: DNA → RNA → protein.
  • Memory trick: “Copy the recipe, cook the protein.”
  • Goal: 100%

Watch for this mistake

  • Thinking every mutation is harmful.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 13: Meiosis and genetic variation

Life Science: Biology · High schoolUnit 3: HeredityNYS standard: HS-LS3-2

Big idea: Meiosis, crossing over and mutation create new combinations.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Siblings with the same parents still look different. Meiosis shuffles the genes.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 2 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Meiosis makes sex cells. First, matching chromosomes from each parent pair up.
  • Crossing over: partner chromosomes trade pieces, making new combinations.
  • Meiosis I: the partners separate into two cells, each with half the number.
  • Meiosis II: the copies separate. Four sex cells, each one different.
  • At fertilization, egg and sperm join. In humans, 23 plus 23 makes 46 again.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

How many chromosomes are in a human egg cell?

Answer (for the teacher): 23

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Environmental factors can affect…

  • A. How genes are expressed
  • B. Nothing about traits

Answer (for the teacher): How genes are expressed

Leave on the board

  • Meiosis and genetic variation
  • Big idea: Meiosis, crossing over and mutation create new combinations.
  • Memory trick: “Halve it, shuffle it, join it.”
  • Goal: 100%

Watch for this mistake

  • Mixing up mitosis (identical cells) and meiosis (varied gametes).

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 14: Inheritance and Punnett squares

Life Science: Biology · High schoolUnit 3: HeredityNYS standard: HS-LS3-2, HS-LS3-3

Big idea: Alleles combine by chance.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Two brown-eyed parents can have a blue-eyed child. Punnett squares predict chances.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 2 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Pea flowers: purple P is dominant, white p is recessive. Both parents are Pp.
  • Each parent passes on only one allele. Put one parent's alleles on top, the other's on the side.
  • Fill each box with one allele from the top and one from the side.
  • PP, Pp, Pp, pp: three purple to one white. The genotype ratio is 1 to 2 to 1.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Bb × Bb: percent chance of bb?

Answer (for the teacher): 25

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Variation comes from…

  • A. Meiosis, fertilization, mutation
  • B. Only the environment

Answer (for the teacher): Meiosis, fertilization, mutation

Leave on the board

  • Inheritance and Punnett squares
  • Big idea: Alleles combine by chance.
  • Memory trick: “Box it, count it.”
  • Goal: 100%

Watch for this mistake

  • Confusing genotype and phenotype.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 15: Evidence for common ancestry

Life Science: Biology · High schoolUnit 4: EvolutionNYS standard: HS-LS4-1

Big idea: Fossils, anatomy and DNA point to shared ancestors.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“A human arm, a whale flipper and a bat wing have the same set of bones.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • A human arm, a bat wing and a whale flipper have the same bones, shown in the same colors. These are homologous structures.
  • In rock layers, deeper is older. Fossils show life changing over time.
  • A branching tree shows common ancestors where lines meet.
  • The more DNA two species share, the more recently they had a common ancestor.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Species A and B share 98% of their DNA; A and C share 85%. A's closest relative?

  • A. B
  • B. C

Answer (for the teacher): B

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Branching diagrams of ancestry are called…

  • A. Cladograms
  • B. Food webs

Answer (for the teacher): Cladograms

Leave on the board

  • Evidence for common ancestry
  • Big idea: Fossils, anatomy and DNA point to shared ancestors.
  • Memory trick: “Same bones, shared roots.”
  • Goal: 100%

Watch for this mistake

  • Thinking humans evolved from modern apes (we share common ancestors).

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 16: Natural selection

Life Science: Biology · High schoolUnit 4: EvolutionNYS standard: HS-LS4-2, HS-LS4-4

Big idea: Variation + selection + time = evolution.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Bacteria that survive an antibiotic reproduce, so the population becomes resistant.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model. This lesson has 3 3D videos in a row: press Next and ▶ Play for each part.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • Variation: these beetles differ in color, and color is inherited.
  • Selection: birds catch the beetles they can see. Green beetles stand out on brown ground.
  • Brown beetles survive and reproduce more, so each generation has more brown beetles.
  • If the ground turns green, green beetles are favored instead. Selection depends on the environment.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Antibiotic resistance spreads because…

  • A. Resistant bacteria survive and reproduce
  • B. Bacteria decide to change

Answer (for the teacher): Resistant bacteria survive and reproduce

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

DNA similarity shows…

  • A. Relatedness
  • B. Diet

Answer (for the teacher): Relatedness

Leave on the board

  • Natural selection
  • Big idea: Variation + selection + time = evolution.
  • Memory trick: “Populations evolve, not individuals.”
  • Goal: 100%

Watch for this mistake

  • Thinking organisms change on purpose.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 17: Adaptation and changing trait frequency

Life Science: Biology · High schoolUnit 4: EvolutionNYS standard: HS-LS4-3

Big idea: Helpful traits become more common over generations.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“In 1800s England, soot darkened tree bark, and dark peppered moths became more common.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • A population has variation: different versions of a trait.
  • A helpful trait means more survivors and more offspring, so the trait becomes more common each generation.
  • When conditions change, the helpful trait can change too.
  • Bacteria show it fast: an antibiotic removes the ones that cannot resist it.
  • The resistant trait becomes common. That is adaptation by natural selection.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Dark moths went from 20% to 70% of a population. By how many percentage points did they rise?

Answer (for the teacher): 50

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Natural selection acts on…

  • A. Existing variation
  • B. Wishes

Answer (for the teacher): Existing variation

Leave on the board

  • Adaptation and changing trait frequency
  • Big idea: Helpful traits become more common over generations.
  • Memory trick: “Count the trait, track the shift.”
  • Goal: 100%

Watch for this mistake

  • Thinking one organism adapts during its own life.

Students do not need accounts; progress stays on each device.

Notes for the teacher

Lesson 18: Speciation and extinction

Life Science: Biology · High schoolUnit 4: EvolutionNYS standard: HS-LS4-5

Big idea: Isolation can form species; fast change can cause extinction.

Do now5 min

Read this aloud (it is the lesson's hook). Students think, then tell a partner what they notice.

“Galápagos finches on different islands evolved different beak shapes.”

Watch together10 min
  1. Open the lesson link on the board.
  2. Press Next to the 🎬 Watch in 3D step and press ▶ Play. Students can drag to turn the model.
  3. Press Next to the Movie step and press ▶ Play.

The video says:

  • One population can mix and interbreed freely.
  • A river or mountain splits the population. Now the groups cannot mix.
  • Over many generations, different mutations and different selection make the groups different.
  • If they can no longer interbreed, even when together, they are two separate species.
  • If the environment changes faster than a species can adapt, it can go extinct.
Try it15 min

Students open the same lesson on their own device (or work with the board). Press Next to Try it.

Try it together first:

Two isolated populations can no longer interbreed. This is…

  • A. Speciation
  • B. Extinction

Answer (for the teacher): Speciation

🧱 Build it: the lesson's short 3D build game. Let students play it after Try it. Its score never changes grades.

If time is left, students play the lesson's game steps (they show up between the videos and Check).

Check5 min

Students press Next to Check and answer the 4 questions on their own device. Goal: 100%. 95% or more is Mastered. “Not yet” means try again; students may retry.

Exit ticket5 min

Read this question aloud. Students write the answer on a slip of paper with no name or with a class number, and hand it in.

Environmental change can lead to…

  • A. Speciation or extinction
  • B. Nothing

Answer (for the teacher): Speciation or extinction

Leave on the board

  • Speciation and extinction
  • Big idea: Isolation can form species; fast change can cause extinction.
  • Memory trick: “Split, separate, specialize.”
  • Goal: 100%

Watch for this mistake

  • Thinking evolution always makes organisms ‘better’ in every way.

Students do not need accounts; progress stays on each device.

Notes for the teacher